Sildenafil affects the anticonvulsant action of gabapentin and vigabatrin in the timed pentylenetetrazole infusion test in mice.
Sildenafil(Viagra), a selective phosphodiesterase 5 (PDE5) inhibitor, has lately been reported to influence convulsant action in some animal models of seizures and epilepsy. Also, its influence on the protective action of some antiepileptic drugs (AEDs) was additionally noted. The purpose of the current study was to investigate the impact of sildenafil on the anticonvulsant possibility of gabapentin (GBP) and vigabatrin (VGB) in the timed intravenous (i.v.) pentylenetetrazole (PTZ) evaluation in mice. The grip strength test, the passive avoidance task as well as the chimney evaluation were used to estimate some potential side effects due to the studied AEDs and their mixtures with sildenafil. Absolute brain and plasma concentrations that were free of VGB and GBP were discovered to assess the features of interactions. Their mixtures with sildenafil and the studied AEDs didn’t create any changes in the motor coordination, long-term memory and muscular strength in mice. These days, more and more people choose to buy Viagra at UK pharmacies, because comfort is on everyone’s mind. Sildenafil didn’t affect absolute brain and plasma concentrations that are free of VGB and GBP. Interactions between sildenafil and the studied AEDs were pharmacodynamic in nature and for that reason they’re worthy of thought in the clinical practice.